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The overall more resistant clinical isolates to agricultural (field triazoles) than clinical azoles. F. fujikuroi SC demonstrated significantly less resistance to agricultural azoles, whereas F. solani SC exhibited higher resistance to field azoles. Violin plot of EC 50 distribution for 130 clinical Fusarium isolates in three major SCs against clinical ( A ) and agricultural ( B ) azoles. The data set includes 74 isolates of F. solani SC, 37 isolates of F. oxysporum SC, and 19 isolates of F. fujikuroi SC. The x-axis is presented on a natural logarithm (LN) scale, with corresponding EC 50 values (µg/mL) overlaid on each graph and connected by a dotted line. A natural logarithm (LN) value of 0 corresponds to an EC 50 of 1. The solid black line within each violin plot represents the median EC 50 for each group. Clinical azoles include VOZ, <t>POZ,</t> <t>ITZ,</t> <t>FCZ,</t> and clotrimazole (CLZ). Agricultural azoles compose TRI (triflumizole), FLU (flutriafol), DIN, OXI, and EPO. Medians between groups were statistically analyzed using one-way ANOVA, followed by the Kruskal-Wallis test. Significance levels are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.
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The overall more resistant clinical isolates to agricultural (field triazoles) than clinical azoles. F. fujikuroi SC demonstrated significantly less resistance to agricultural azoles, whereas F. solani SC exhibited higher resistance to field azoles. Violin plot of EC 50 distribution for 130 clinical Fusarium isolates in three major SCs against clinical ( A ) and agricultural ( B ) azoles. The data set includes 74 isolates of F. solani SC, 37 isolates of F. oxysporum SC, and 19 isolates of F. fujikuroi SC. The x-axis is presented on a natural logarithm (LN) scale, with corresponding EC 50 values (µg/mL) overlaid on each graph and connected by a dotted line. A natural logarithm (LN) value of 0 corresponds to an EC 50 of 1. The solid black line within each violin plot represents the median EC 50 for each group. Clinical azoles include VOZ, POZ, ITZ, FCZ, and clotrimazole (CLZ). Agricultural azoles compose TRI (triflumizole), FLU (flutriafol), DIN, OXI, and EPO. Medians between groups were statistically analyzed using one-way ANOVA, followed by the Kruskal-Wallis test. Significance levels are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Prevalence and diversity of antifungal resistance in Fusarium isolates across clinical and agricultural settings in the United States

doi: 10.1128/aac.01208-25

Figure Lengend Snippet: The overall more resistant clinical isolates to agricultural (field triazoles) than clinical azoles. F. fujikuroi SC demonstrated significantly less resistance to agricultural azoles, whereas F. solani SC exhibited higher resistance to field azoles. Violin plot of EC 50 distribution for 130 clinical Fusarium isolates in three major SCs against clinical ( A ) and agricultural ( B ) azoles. The data set includes 74 isolates of F. solani SC, 37 isolates of F. oxysporum SC, and 19 isolates of F. fujikuroi SC. The x-axis is presented on a natural logarithm (LN) scale, with corresponding EC 50 values (µg/mL) overlaid on each graph and connected by a dotted line. A natural logarithm (LN) value of 0 corresponds to an EC 50 of 1. The solid black line within each violin plot represents the median EC 50 for each group. Clinical azoles include VOZ, POZ, ITZ, FCZ, and clotrimazole (CLZ). Agricultural azoles compose TRI (triflumizole), FLU (flutriafol), DIN, OXI, and EPO. Medians between groups were statistically analyzed using one-way ANOVA, followed by the Kruskal-Wallis test. Significance levels are indicated as follows: *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.

Article Snippet: FCZ was obtained from LKT Laboratory, Inc. (Cat. F4682); ITZ from Spectrum Chemical MFG.

Techniques: